Learn about Levothyroxine impurity and related information. Levothyroxine, or L-thyroxine, is an artificial form of the thyroxine hormone that is used to cure related ailments. The thyroid hormones, triiodothyronine (T3) and thyroxin (T4) are primarily responsible for regulation of metabolism. Tyrosine-based these two hormones are produced by the thyroid gland. Both T3 and T4 are used to treat thyroid hormone deficiency known as hypothyroidism, including the severe form known as myxedema coma. The pharmaceutical name of levothyroxine sodium (T4) is Levothyroxine more pure, synthetic form of Thyroid.Checkout https://www.lq3pharma.com/levothyroxine/ for more info.
Introduced in the 1950s it is typically used in the cure for people with hypothyroidism that regularly requires lifelong thyroid hormone remedy. This is also used to treat subclinical hypothyroidism which is defined by araised TSH level and is milder than usual. Such people may be asymptomatic and can’t be predicted whether they should be treated or they don’t require any sort of treatment.
This Impurity is contraindicated in the following:
This Impurity degrades rapidly with exposure to light, moisture, and oxygen.
Thyroid disorder called thyrotoxicosis
Sort of heart, coronary artery disease, or any history of blood clots
diabetes (insulin or oral medication dosages must be changed when you start levothyroxine medicine)
low bone mineral density or osteoporosis
any problems with your pituitary gland
food or drug allergy
untreated adrenal gland disorder
Not suggested in people who have had a recent heart attack.
During the manufacturing process or storage of the drug elements, impurities present in the form of by-products or so called process impurities are possible.
All impurities of Levothyroxine obtained are given below.
Levothyroxine T4-Amine O-methyl Impurity / O-Methyl-Tetraiodothyroethylamine
Levothyroxine acetamide Impurities (T4-Acetamide)
Levothyroxine EP Impurities A, Levothyroxine
Levothyroxine EP Impurities C, T3-Acetic Acid (USP)
Levothyroxine EP Impurities D, T4-Acetic Acid (USP) and more.